Repositioning of Atorvastatin for the treatment of COVID-19. Statins such as Atorvastatin are potent cholesterol-lowering dugs that are tested against COVID-19. Statins could be proven beneficial particularly against SARS-CoV-2-induced cardiovascular manifestations. Explore the live graph.
Mechanisms by which Eculizumab (Soliris) may benefit COVID-19 patients with respiratory distress syndrome
Eculizumab is a biologic therapy, a complement C5 inhibitor, and has recently shown promise in COVID-19. The graph provides an important step towards elucidating the MoA of this drug in COVID-19. Explore the live graph.
Chlorphenamine is a known antihistamine used to treat the symptoms of allergic conditions such as allergic rhinitis, whereas Ibuprofen is a potent nonsteroidal anti-inflammatory drug (NSAID). Combination of Chlorpheniramine and ibuprofen combination have long been postulated to treat common cold and its symptoms. Role and efficacy in the COVID-19 remains to be elucidated. Explore the […]
Amantadine is an anti-viral drug which is also used in Parkinson’s disease. The drug has been shown to reduce viral load in the context of the influenza virus, and in the COVID-19 setting, it may be able to decrease the viral load in SARS-CoV-2 positive patients. Explore the live graph.
Ivermectin is an anti-parasitic agent that has shown promise against the virus in vitro. Its potential mechanism of action (MoA) in COVID-19, is poorly understood. Explore the live graph.
Tocilizumab (Acterma) is an immunosuppressive drug (IL-6 inhibitor) mainly used in the treatment of rheumatoid arthritis and is currently being tested in COVID-19 patients. Explore the live graph.
Acalabrutinib is an anti-cancer medicine (tyrosine kinase inhibitor) showing promise in early studies. Its potential mechanism of action (MoA) is poorly understood. If understood better, more anti-cancer drugs can be rationalized against COVID-19. MoA elements include genes, and pathways that may explain the MoA of the drug in particularly ameliorating cytokine storm-related features in COVID-19. […]
Adverse Event considerations for repositioning remdesivir, hydroxychloroquine, chloroquine, and interleukin (IL)-6 inhibitors in COVID-19 patients
Patients with COVID-19 often also face cardiovascular challenges and associated comorbidities. Understanding how repositioned drugs to treat COVID-19 may impact the cardiovascular health of patients is important.Live Graph Detail: Targets of the drugs are included (e.g. RNA dependent RNA polymerase, target of remdesivir, IL-7, target of IL-6 inhibitors). Explore the live graph.
There is growing amount of evidence to suggest the use of pharmaceuticals that target the Renin-Angiotensin System (e.g. angiotensin 1-7, ARBs and ACE inhibitors) may be beneficial in the treatment of COVID-19. This graph shows the interconnections among these classes of drugs, and SARS-CoV-2 via key genes implicated in this pathway. mediated. Explore the live […]
Azithromycin is being tested in COVID-19 patients. Although it is a potent antibiotic, in the COVID-19 setting, it likely acts as an anti-inflammatory agent. Its exact MoA in the disease, however, remains to be elucidated. Explore the live graph.
Vitamin D supplementation has been shown to protect against SARS-COV-2 infection, and could be particularly helpful for patients that exhibit shortage of vitamin D (e.g. seniors, immunocompromised patients) leading to complications such as cardiovascular comorbidities. This graph explains the mechanism of action of vitamin D in COVID-19 via key genes implicated. Explore the live graph.
Dexamethasone is a widely-used and safe steroid that has been studied in the context of treating viral respiratory disorders, and is THE FIRST drug that has been shown to reduce mortality of patients with severe COVID-19. Explore the live graph.
Lopinavir/Ritonavir (Kaletra) is a combination of the antivirals Lopinavir and Ritonavir, that were originally designed to inhibit HIV from replicating by binding to the protease. Similarly, it has been postulated that the drug could also bind to the protease of SARS-CoV-2. The drug is currently being tested for the treatment of COVID-19. Explore the live […]
In addition to respiratory symptoms, novel findings have shown vascular complications in a series of patients with COVID-19, suggesting that COVID-19 is more to a respiratory infection caused by SARS-CoV-2. This graph illustrates some of the possible mechanisms (genes) by which these effects of SARS-CoV-2 may be mediated. Explore the live graph.
The graph visualizes the relationships between genes ACE2 and TMPRSS2 and specific manifestations of COVID-19, such as Acute Lung Injury, ARDS and Lung Fibrosis through a network of specific biological entities such as Cell Types, Pathways and Anatomical Locations that are likely implicated in the pathogenesis of these disease symptoms. Explore the live graph.
Find genes and pathways related to Duchenne and PDE5. Use Vizit live graph to explore Duchenne Muscular Dystrophy. Explore the live graph.
Could Multiple Sclerosis be linked to the Microbiome? Use Biovista Vizit, a brainstorming tool for scientists. Explore the live graph.
“Live graph” of PPARgamma associated with common drugs and two major diseases, Alzheimer’s and Diabetes. Explore the live graph.
Genes and Pathways unraveling mitochondrial role in Cancer Metastasis. Created with Biovista Vizit. Explore the live graph.
Repurposing Diabetes drugs for Alzheimer's disease. View pathways associated with the action of Exenatide in Alzheimer's.
Olfactory impairment: early marker for Alzheimer’s? Explore the live graph.
View and explore bibliographical connections for genes in the central oscillator of the biological clock with Biovista Vizit. Explore the live graph.
Explore immune checkpoint blockade (PD-1, CTLA-4) in cancer immunotherapy with Biovista Vizit. Explore the live graph.
Find drugs common to both Parkinson’s and Alzheimer’s diseases using Biovista Vizit. Explore the live graph.
A visual exploration of the link between statin use and the risk of Diabetes in a subpopulation of patients with subclinical hypothyroidism. Explore the live graph.
Use Biovista Vizit to study how are Periodontitis and Rheumatoid Arthritis are related with regards to the microbiome. Explore the live graph.
Start exploring how Genes related to Cognition affect Epilepsy, Autism or Muscular Dystrophy with Biovista Vizit. Explore the live graph.
Autophagy is a highly complex biological process seen in various Tissues and implicated in different Diseases. Explore the live graph.
Check out common Genes between Rheumatoid Arthritis and Lupus and retrieve relevant papers with Biovista Vizit. Explore the live graph.
Incretin mimetics or GLP-1 receptor agonists are commonly used in Type 2 Diabetes. Recent evidence favors their use for the treatment of Parkinson’s disease. Explore the live graph.
Find genes related to Parkinson’s disease and Autophagy, with Biovista Vizit. Explore the live graph.
Find Biomarkers related to Amyotrophic lateral sclerosis with Biovista Vizit. Explore the live graph.
Mechanism of action of Pirlindole in Multiple Sclerosis. Explore the live graph.
Explore the mechanism of action of Dinoprostone with Biovista Vizit. Explore the live graph.
Tau protein related post-translational modifications in Alzheimer’s disease and other Tauopathies. Explore the live graph.
Metformin, a multifaceted drug for Diabetes, Alzheimers, Osteoporosis but also Pancreatic Cancer and Hypothyroidism. Explore the live graph.
Association of microbiome organisms to Regulatory T Cell function in cancer and inflammation. Explore the live graph.
Explore p53 Pathways and Autophagy related drugs with Vizit. Explore the live graph.
Drugs related to Breast Cancer and CDK4/6 gene. Explore the live graph.
Vizit includes categories for Clinical terms, Diagnostic Procedures & Organisms! Explore the live graph.
Autophagy impairment is shared by various diseases. Explore the live graph.
Visualize molecular links between RORgamma and IL17 mediated responses in Psoriasis. Explore the live graph.
Study microbiota of patients treated with TNF inhibitors with Biovista Vizit. Explore the live graph.
Managing infections and autoimmunity with Remicade and Ribavirin. Explore the live graph.
Find Biomarkers and explore Pathways for Diabetes and Breast Cancer. Explore the live graph.