Mechanistic analysis of Azithromycin

June 19, 2020COVID-19, Vizit Graphs

Azithromycin is being tested in COVID-19 patients. Although it is a potent antibiotic, in the COVID-19 setting, it likely acts as an anti-inflammatory agent. Its exact MoA in the disease, however, remains to be elucidated. Explore the live graph.

Administration of vitamin D could help fight COVID-19

June 19, 2020COVID-19, Vizit Graphs

Vitamin D supplementation has been shown to protect against SARS-COV-2 infection, and could be particularly helpful for patients that exhibit shortage of vitamin D (e.g. seniors, immunocompromised patients) leading to complications such as cardiovascular comorbidities. This graph explains the mechanism of action of vitamin D in COVID-19 via key genes implicated. Explore the live graph.

Lopinavir/Ritonavir mechanism of action analysis in COVID-19

June 19, 2020COVID-19, Vizit Graphs

Lopinavir/Ritonavir (Kaletra) is a combination of the antivirals Lopinavir and Ritonavir, that were originally designed to inhibit HIV from replicating by binding to the protease. Similarly, it has been postulated that the drug could also bind to the protease of SARS-CoV-2. The drug is currently being tested for the treatment of COVID-19. Explore the live … Read More

ACE2, TMPRSS2, Acute Lung Injury, ARDS, and Lung Fibrosis

June 19, 2020COVID-19, Vizit Graphs

The graph visualizes the relationships between genes ACE2 and TMPRSS2 and specific manifestations of COVID-19, such as Acute Lung Injury, ARDS and Lung Fibrosis through a network of specific biological entities such as Cell Types, Pathways and Anatomical Locations that are likely implicated in the pathogenesis of these disease symptoms. Explore the live graph.

Project Prodigy vs COVID-19

A different paradigm The current COVID-19 pandemic from the SARS-CoV-2 virus infection requires all of us to think and act out of the box in order to respond to this global challenge effectively and expeditiously. Here, we share a component of our Project Prodigy AI, called Biovista Vizit. Vizit helps researchers generate hypotheses and test … Read More