By Eftychia Lekka and Vassilis Virvilis The latest release of Biovista Vizit (May 2025) brings the integration of the MATISSE pocket binding similarity algorithm by SoftMining. MATISSE is a dynamic binding pocket analysis tool that uses short molecular dynamics (MD) simulations to capture the flexible nature of protein active sites. It offers detailed geometric, topological, … Read More
Repositioning of Atorvastatin for the treatment of COVID-19. Statins such as Atorvastatin are potent cholesterol-lowering drugs that are tested against COVID-19. Statins could be proven beneficial particularly against SARS-CoV-2-induced cardiovascular manifestations. Explore the live graph.
Chlorphenamine is a known antihistamine used to treat the symptoms of allergic conditions such as allergic rhinitis, whereas Ibuprofen is a potent nonsteroidal anti-inflammatory drug (NSAID). Combination of Chlorpheniramine and ibuprofen combination have long been postulated to treat common cold and its symptoms. Role and efficacy in the COVID-19 remains to be elucidated. Explore the … Read More
Eculizumab is a biologic therapy, a complement C5 inhibitor, and has recently shown promise in COVID-19. The graph provides an important step towards elucidating the MoA of this drug in COVID-19. Explore the live graph.
Amantadine is an anti-viral drug which is also used in Parkinson’s disease. The drug has been shown to reduce viral load in the context of the influenza virus, and in the COVID-19 setting, it may be able to decrease the viral load in SARS-CoV-2 positive patients. Explore the live graph.