Adverse Event considerations for repositioning remdesivir, hydroxychloroquine, chloroquine, and interleukin (IL)-6 inhibitors in COVID-19 patients

June 19, 2020COVID-19, Vizit Graphs
Adverse Event considerations for repositioning remdesivir, hydroxychloroquine, chloroquine, and interleukin (IL)-6 inhibitors in COVID-19 patients

Patients with COVID-19 often also face cardiovascular challenges and associated comorbidities. Understanding how repositioned drugs to treat COVID-19 may impact the cardiovascular health of patients is important.Live Graph Detail: Targets of the drugs are included (e.g. RNA dependent RNA polymerase, target of remdesivir, IL-7, target of IL-6 inhibitors). Explore the live graph.

Lopinavir/Ritonavir mechanism of action analysis in COVID-19

June 19, 2020COVID-19, Vizit Graphs
Lopinavir/Ritonavir mechanism of action analysis in COVID-19

Lopinavir/Ritonavir (Kaletra) is a combination of the antivirals Lopinavir and Ritonavir, that were originally designed to inhibit HIV from replicating by binding to the protease. Similarly, it has been postulated that the drug could also bind to the protease of SARS-CoV-2. The drug is currently being tested for the treatment of COVID-19. Explore the live … Read More

Possibly implicated genes in SARS-CoV-2-mediated blood vessel disease

June 19, 2020COVID-19, Vizit Graphs
Possibly implicated genes in SARS-CoV-2-mediated blood vessel disease

In addition to respiratory symptoms, novel findings have shown vascular complications in a series of patients with COVID-19, suggesting that COVID-19 is more to a respiratory infection caused by SARS-CoV-2. This graph illustrates some of the possible mechanisms (genes) by which these effects of SARS-CoV-2 may be mediated. Explore the live graph.

ACE2, TMPRSS2, Acute Lung Injury, ARDS, and Lung Fibrosis

June 19, 2020COVID-19, Vizit Graphs
ACE2, TMPRSS2, Acute Lung Injury, ARDS, and Lung Fibrosis

The graph visualizes the relationships between genes ACE2 and TMPRSS2 and specific manifestations of COVID-19, such as Acute Lung Injury, ARDS and Lung Fibrosis through a network of specific biological entities such as Cell Types, Pathways and Anatomical Locations that are likely implicated in the pathogenesis of these disease symptoms. Explore the live graph.